The long pepper can be pharmacologically classified as an adaptogenic or stress response regulating medicinal herb, with a broad spectrum of therapeutic bioactivity.

Piperlongumine, piperine, and other amide alkaloids have been identified as the major and structurally unique bioactive molecules of the plant.

Senescent “zombie” cells are cells that no longer divide and enter a permanent state of cell-cycle arrest (where they’re no longer part of a healthy cell cycle).

Because they’re not actually living, yet they don’t die, they’re often nicknamed “zombie cells”.

These cells release chemicals which act as poisons, causing damage to nearby healthy cells, facilitating a downward spiral, and triggering aging and age-related aliments.

As we grow older, senescent cells accumulate in our bodies. This process is also known as Cellular Senescence.

The word “senolytic” comes from a combination of “senescence” and “lytic”, the Greek word for destroying.

Senolytics are certain small molecules that can selectively kill senescent “zombie” cells, thereby promoting healthy aging.

Piperlongumine (also called piplartine or piperlongumin) is an amide alkaloid constituent of the fruit of the long pepper (piper longum), that has been rigorously studied with well-documented health benefits.

Piperlongumine has been identified as a natural, plant-derived, potent senolytic, able to selectively kill senescent “zombie” cells and protect against age-related disorders.

Each 1,000 mg serving of our patent pending Fermented Long Pepper Extract contains 10 mg (1%) of piperlongumine.

Prior to our 30:1 ratio extraction process, our long pepper undergoes a 96-hour fermentation, which has multiple benefits. 

Research shows that fermentation increases the amount of beneficial micro-organisms and bioactive substances, such as phenolic compounds, amino acids, and antioxidants.

Fermentation can also improve the bioavailability of the supplement and the body’s ability to better absorb it.

Research has shown that the long
pepper is Generally Recognized as Safe (GRAS) and consumption is safe and well-tolerated by the body.

("Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications", Molecules
Journal 2019, 24, 1364)

The purity levels in our Fermented Long Pepper Extract are always greater than 99%.

We use an industry-standard High Performance Liquid Chromatography (HPLC) method to test the purity levels.

For more details, please visit our Quality & Testing page (click here).

Our Fermented Long Pepper Extract utilizes a potent extraction process at a 30:1 extract ratio, meaning that a single, 1,000mg serving of Fermented Long Pepper Extract is equivalent to 30,000mg of standardized long pepper powder.

Yes! Our Fermented Long Pepper Extract is gluten free.

As per FDA requirements, in order to claim gluten free status, the product must contain less than 20 parts per million (ppm) of gluten.

We test our product utilizing a R5 Sandwich ELISA method.  We make our lab tests transparent on our Quality & Testing page (click here).

Our facility does produce products that contain gluten, however, through proper sourcing, cleaning, storage, production, and testing protocols (like the lab tests mentioned above), we are able to keep our product safe and gluten free.

Yes! Our Fermented Long Pepper Extract is 100% vegan and plant based, including our capsule shell, made of glutinous rice starch (which is gluten free) and is easily digested and absorbed by the body.

Yes! Our Fermented Long Pepper Extract is free of genetically modified organisms (GMOs).

Yes! We are pleased to say that our Fermented Long Pepper Extract is an all-natural product.

We don't use any fillers or additives or synthetic agents.

As part of our ongoing commitment to transparency, we strive to give you as much comfort as possible in our product, through bringing you insight into both our production quality and supporting evidence of benefits. 

There are numerous, well-documented health benefits of the long pepper (scientifically known as 'piper longum') and piperlongumine.

Piperlongumine is a potent, all-natural senolytic agent, which is able to selectively target and kill senescent "zombie" cells.

Senolytic agents have shown interesting anti-aging bioactivities, which have led to great interest in their use by the pharmaceutical industry.

There has been significant research on these compounds and topics, supporting a wide range of benefits. 

We've included a deep selection of relevant scientific studies and research articles on our Research page (click here to visit).

Absolutely!

Each batch of our product undergoes rigorous and detailed 3rd party lab testing, to make sure our ingredients are consistently of the highest quality and meet the best of international standards.

We test for purity, heavy metals, solvents, pesticides, and bacteria.

We strive to give our customers confidence, and in full transparency, we make our results available on our Quality & Testing page (click here to visit).

Yes!

Our manufacturing facilities are GMP (Good Manufacturing Practice) Certified.

GMP is a system for ensuring that products are consistently produced and controlled according to quality standards.

It is designed to minimize the risks involved in any food or pharmaceutical production.

Yes!

Our manufacturing facilities are ISO (International Organization for Standardization) 9001 Certified.

This is an internationally recognized quality management system (QMS) standard that demonstrates the ability to consistently provide products and services that meet customer and regulatory requirements.

Unlike nootropics (cognitive enhancers) or energy boosters, where you might be able to feel a short-term, immediate physical or mental impact, our Fermented Long Pepper Extract works on a cellular level, as a senolytic agent, which isn’t necessarily physically discernible.

However, some customers do report tangible improvements after taking our Fermented Long Pepper Extract , which include improved biomarkers (in blood tests), increased immunity (getting sick less often and quicker recovery time), improved memory and cognition (less brain fog), less muscle/joint soreness, better digestion, and increased energy.

The total empty size inside each capsule is large enough to contain 680mg.

We put 500mg of Fermented Long Pepper Extract inside each capsule.

We don't use any fillers, as we want to keep our product as natural and pure as possible.

Depending on the natural settling of the powder, there may be some empty space inside the capsule, which would be normal.

We at CellFend try to keep our products as pure and natural as possible.

As such, we don't use coating, dilutions, or masking agents to conceal the smell or taste.

So if your bottle has a bit of a funny smell to it, then don't worry! It's natural...

Our capsules are made of glutinous rice starch, which is gluten free.

The name "glutinous" is misleading, as it's actually gluten free.

The name simply comes from the consistency of that rice varietal when cooked.

Our capsules are also vegan (many non-vegan capsules contain gelatin, which is an animal byproduct).

Each capsule is 500mg.

One serving is equal to 2 capsules (1,000mg).

Take one serving (2 capsules) once a day with food, or as directed by a health care professional.

Yes, our site is secure. We take security very seriously. We use a 'HTTPS' secure encrypted communication protocol, to make sure that your personal and payment information is safe.

Our servers are Payment Card Industry Data Security Standard (PCI DSS) Level 1 compliant with a team of people dedicated to platform security.

We accept Visa, MasterCard, American Express, Discover, JCB, Diners Club, Apple Pay, Google Pay, PayPal, Amazon Pay, Elo, and Shop Pay.

If you have a discount code to use, then you can simply type it into the "Discount code" box located on the payment screen of your check-out process.

Make sure that you click the "Apply" button after you enter the code.

You'll then see the discount applied and your total price should be adjusted.

Due to the nature of our product, all orders are considered final sale, and payments made to us are non refundable, unless the product appears to be defective.

If the product appears to be defective, then within 30 days of your purchase, please take a picture of the product defects and email it to us at sales@cellfend.com, along with a picture of the packing slip with your relevant order information.

Customer satisfaction is very important to us, and we want to work through any issues you may have, in order to make it a positive experience for you.

If you have any issues at all, please feel free to email us.

Individual Purchase:
You will be billed immediately upon purchase.

Monthly 'pay-as-you-go' Subscription Plans:
You will be billed immediately upon purchase for your first months' supply. For subsequent months' supplies, you will automatically be billed at the beginning of every month (unless cancelled).

Quarterly, Semi-Annual, and Annual Prepaid Subscription Plans:
You will be billed immediately upon purchase of the plan. Your plan will automatically renew at the end of your subscription period, at which point, you will automatically be billed for the next cycle (unless cancelled).

With a monthly 'pay-as-you-go' subscription, you can sign up for monthly deliveries, so you don't have to worry about ordering every month.

You will pay upfront for whichever plan you choose (3, 6, or 12 months).

For instance, if you choose a 3 month plan, then you will be billed for all 3 months upfront.

You will receive a discount on your cost per bottle by signing up for this subscription service, even though you're still only paying for 1 month at a time.

Your bottles will be shipped to you monthly.

Your monthly 'pay-as-you-go' subscription will renew automatically at the end of each month (unless you cancel).

With a prepaid plan, you can sign up for monthly deliveries for a period of 3, 6, or 12 months.

You will pay upfront for whichever plan you choose (3, 6, or 12 months).

For instance, if you choose a 3 month plan, then you will be billed for all 3 months upfront.

You will receive a significant discount on your cost per bottle by paying upfront.

Your bottles will be shipped to you monthly.

Your prepaid plan will renew automatically at the end of the 3, 6, or 12 month period.

We will remind you of this renewal 30 days prior by email.

You can cancel the renewal of your subscription at any time by contacting us by email at sales@cellfend.com.

You will not receive a refund for the fees you already paid for your current subscription period and you will continue to receive products ordered until the end of your current subscription period.

The pricing of our quarterly, semi-annual, and annual plans offers a savings to customers who commit to a longer-term subscription. The longer the commitment, the greater the savings.

These prepaid subscriptions are considered final sale, so if you cancel in the middle of your plan, then you will continue to receive the remaining bottles throughout the duration of your plan, and the cancellation will take effect at the end of your plan before renewal.

Please contact our Sales Team at sales@cellfend.com if you have any questions about subscriptions.

You can place a hold on your account or adjust your delivery schedule by contacting our sales team at sales@cellfend.com.

We offer 3 delivery methods:

Standard
(3-5 business day shipping)
Free!

Expedited
(2-day shipping)
$5.69

Priority
(next-day shipping)
$12.80